SWINE RESEARCH SNAPSHOT
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Antimicrobial Peptides: the new solution to antibiotic-resistance
Restrictions on antibiotic use
coming December 1st 2018
Antimicrobial Peptides (AMP)
are a growing area in research
Synthetic AMP show promising
activity against bacteria
Challenges with AMP lie in
their stability inside the body
Longer stability results in
longer antimicrobial action
New regulations over the use of Medically Important
Antimicrobials in livestock are coming December 2018.
Reduced access to antibiotics leaves producer's livestock
vulnerable to outbreaks of bacterial infections. Antimicrobial
Peptides (AMP) are potential alternatives to antibiotic use.
AMP function differently from antibiotics, meaning bacteria
have a reduced likelihood of developing resistance. This
make AMP attractive candidates for feed additives and
treatments for bacterial infections.
PROGRESS IN AMP PRODUCTION:
While effective, natural AMP pose two main challenges: poor
stability when tested in physiological conditions; and complex
structure leading to expensive production. These challenges
can be overcome through the design of synthetic AMP. Four
synthetically designed peptides where tested to observe their
antimicrobial activity against two strains of bacteria under
physiological conditions. Potential recombinant production of
the AMP in yeast cells was also studied.
1) All AMP tested showed strong antimicrobial activity at
2) Of the AMP tested, two maintained stability for up to 7
hours in 25% serum
3) The two most stable AMP have potential for recombinant
production in yeast
Synthetic AMP may be the future of antimicrobial therapy
in veterinary medicine.