Effective: 06/28/2021 01-2021 C18041-A, C18042-A, C18044-A, C18046-A, C18111-A Page 2 of 3
Is testosterone level normal for lab reference range?
Will testosterone replacement therapy be prescribed
before starting treatment?
Does member have history of
prostate cancer?
Prevention of Osteoporosis in Postmenopausal Women
Is diagnosis of osteopenia (T-score between -1.0
and -2.5) AND high risk for osteoporosis fracture?
Fracture Risk Assessment Tool risk ≥3.0%
for hip fracture OR ≥ 20% for any major
osteoporosis related fracture OR multiple
risk factors for fracture?
Was there failure of oral OR IV bisphosphonate
despite compliance, including new fracture OR
reduction in BMD per recent DEXA scan, after
TWO years of oral bisphosphonate?
Was there a contraindication OR severe
intolerance to oral bisphosphonate
(current upper GI symptoms, inability to
swallow OR inability to remain in upright
position after oral bisphosphonate
Does member have a stable BMD without
fractures?
Has BMD has worsened OR member had
fractures?
Glucocorticoid-Induced Osteoporosis
Is member a postmenopausal woman OR man
>50 years of age?
Has member received OR is expected to
receive, prednisone ≥7.5mg/day for > 3
Is member premenopausal woman or man <50
years of age?
Does member have history of fragility
fracture AND received OR is expected to
receive, prednisone ≥7.5mg/day for >3
months?
Was there failure of oral OR IV bisphosphonate
despite compliance (including new fracture OR
reduction in BMD per recent DEXA scan, after
TWO years of oral bisphosphonate)?
Was there a contraindication OR severe
intolerance to oral bisphosphonate
(current upper GI symptoms, inability to
swallow OR inability to remain in upright
position, after oral bisphosphonate
administration)?
While on treatment, does the member have stable
bone mineral density without fractures?
While on treatment, has bone mineral
density has worsened, or member had
Bone Metastases of Cancer AND Multiple Myeloma
Does member have diagnosis of solid tumor with
bone metastases?
Does member have diagnosis of multiple
myeloma?
Does member have diagnosis of castration-resistant prostate cancer with bone metastases?
Increase of Bone Mass in MEN on Androgen Deprivation Therapy for Prostate Cancer WITHOUT Bone Metastases
Is member at high risk for osteoporosis fracture (FRAX risk ≥3.0% for hip fracture OR ≥20% for any major
osteoporosis related fracture OR multiple risk factors for fracture)?
Was there failure of oral OR IV bisphosphonate
despite compliance (including new fracture OR
reduction in BMD per recent DEXA scan, after
TWO years of oral bisphosphonate)?
Was there a contraindication OR severe
intolerance to oral bisphosphonate
(current upper GI symptoms, inability to
swallow OR inability to remain in upright
position, after oral bisphosphonate
administration)?
Increase of Bone Mass in WOMEN on Aromatase Inhibitory therapy for Breast Cancer WITHOUT Bone Metastases
Is member POST-menopausal OR PRE-menopausal with diagnosis of osteoporosis
(T-score < -2.5 OR fragility fracture at hip, spine, wrist, arm, rib OR pelvis)?
Was there failure of oral OR IV bisphosphonate
despite compliance (including new fracture OR
reduction in BMD per recent DEXA scan, after
TWO years of oral bisphosphonate)?
Was there a contraindication OR severe
intolerance to oral bisphosphonate
(current upper GI symptoms, inability to
swallow OR inability to remain in upright
position, after oral bisphosphonate
administration)?
Hypercalcemia of Malignancy
Does member have moderate OR severe
hypercalcemia associated with malignancy?
Is member receiving vigorous saline
hydration with goal of increasing urine
Does member have bone specific alkaline phosphatase > 2 times ULN, OR symptoms related to active Paget’s (pain
at site of pagetic lesion)?
Is there normal serum calcium, phosphorus AND
If ABNORMAL serum calcium,