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Is adolescent between ages 10 to 19 as defined by World Health Organization?
Did member attain expected adult height?
Did bone radiograph show closed epiphyses?
Member is at high risk of GH?
deficiency due to childhood-onset
from ONE of the following:
structural defect or tumor
At least 3 deficiencies of anterior pituitary
hormones (FSH / LH, TSH, ACTH,
Prolactin), pan-hypopituitarism
Is IGF-1 below age AND gender adjusted normal range as provided by physician’s lab?
Member has stopped GH therapy for at least ONE month AND
undergone ONE provocative GH stim test confirming transition
phase GH deficiency AND ONE of the following peak values:
Insulin Tolerance Test:
≤5 ng/ml
Glucagon:
≤3 ng/mL
Arginine:
≤0.4 ng/mL
Arginine + GHRH:
☐ ≤11 ng/mL if BMI is < 25 kg/m2
☐ ≤8 ng/mL if BMI ≥25 and <30 kg/m2
≤4 ng/mL if BMI ≥30 kg/m2
Is there documentation supporting positive response to therapy (for example, increase in total lean body mass, increased
exercise capacity OR increased IGF-1 levels) AND documentation is submitted with request?
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Adult Growth Hormone Deficiency
Did provider submit documentation supporting diagnosis, stim test results, and IGF-1 levels?
Is there a diagnosis of childhood-onset GHD?
Is there a diagnosis of adult-onset GHD?
Is there documentation supporting hormone
deficiency is due to hypothalamic-pituitary
disease from organic or known causes?
Was there 1 GH stim test confirming adult GH
deficiency (insulin tolerance test, arginine+GHRH,
following peak value
tests:
Insulin tolerance t est:
≤5 ng/ml
Arginine+GHRH:
≤11 ng/mL if BMI is < 25 kg/m2
☐ ≤8 ng/mL if BMI ≥25 and <30 kg/m2
≤4 ng/mL if BMI ≥30 kg/m2
Glucagon:
≤3 ng/mL
Arginine:
≤0.4 ng/mL
Macimorelin:
≤2.8 ng/mL
Is there at least 3 deficiency of anterior pituitary
hormones (FSH/LH, TSH, ACTH, Prolactin),
Is IGF-1 below age AND gender adjusted normal
range as provided by physician’s lab?
Is there documentation supporting positive response to therapy (for example, increase in total lean body mass, increased
exercise capacity OR increased IGF-1 levels) AND documentation is submitted with request?
HIV-Associated Cachexia or Wasting
Is there documentation of BMI, weight, and ideal body
weight prior to start of therapy and then after starting
Serostim?
Is member on current use of anti-
retroviral therapy?
Was there inadequate response, intolerable side effects,
or contraindication to megestrol acetate or dronabinol?
Is the BMI <20 kg/m2 prior to starting
Serostim?
Was there weight loss due to other causes such as depression, mycobacterium avium complex, chronic infectious
diarrhea, or malignancy with exception of Kaposi’s sarcoma limited to skin or mucous membranes?
Member has unintentional weight loss of >10% over last 12 months
or >5% over last 6 months?
Is weight <90% of the lower limit
of ideal body weight?
Is there documentation supporting positive response to
therapy (BMI has improved or stabilized)?
Is member on current anti-retroviral
therapy?
Is member currently receiving specialized nutrition
support (IV parenteral nutrition, fluid AND micronutrient
supplements)?
Was 4 weeks of treatment with Zorbtive
previously received?
Additional information the prescribing provider feels is important to this review. Please specify below or submit medical records
Effective: 04/01/2020 C4582-A, C6653-A, C6655-A 12-2019 Page 3 of 4