address inhibitors as appropriate?
Does member have a laboratory confirmed diagnosis?
Does member have history of bleed (for example, prolonged wound bleed, post-surgical or dental bleed, nosebleeds,
menorrhagia, excessive bruising, or family history of bleeding or bleeding disorder)?
Novo-Seven RT (Recombinant Activated Factor VII Concentrate (Factor VIIa))
Member has ONE of the following FDA
approved indications (check one):
Congenital Factor VII deficiency
Hemophilia A or B with Inhibitors
Glanzmann’s thrombasthenia, when refractory to
platelet transfusions, with or without antibodies to
platelets
Is treatment for hemorrhagic complications OR prevention of bleeds in surgical OR invasive procedures?
If an inhibitor is present, is there a treatment plan to
address inhibitors as appropriate?
Feiba (Activated Prothrombin Complex Concentrate)
Will Feiba be used for Hemophilia A or Hemophilia B with inhibitors?
Will Feiba be used for the treatment of hemorrhagic complications, or prevention of bleeds, in surgical, or invasive
procedures, or routine prophylaxis?
If an inhibitor is present, is there a treatment plan to
address inhibitors as appropriate?
Will Obizur be used for acquired Hemophilia A in
adults (for treatment of bleeding episodes)?
Is baseline anti-porcine Factor VIII
inhibitor titer NOT > 20 Bethesda Units?
If inhibitor is present, is there a treatment plan to
address inhibitors as appropriate?
Will Hemlibra be used for prophylaxis of Hemophilia A with or without inhibitors?
Is there severe disease with documentation showing <1% of normal Factor VIII (<0.01 IU/mL)?
Is disease mild or moderate with
documentation showing ≥1% of normal
Factor VIII (≥0.01 IU/mL)?
Is there documentation showing at least
TWO episodes of bleeding into the joints?
Members without inhibitors have tried and failed
OR have documented contraindications to TWO
prophylactic factor VIII replacement products?
Will medication be used for
treatment of acute bleeds?
Provider confirms that member will D/C any
use of factor VIII products as prophylactic
therapy while on Hemlibra (on-demand
usage may be continued)?
Cumulative amount of >100 U/kg/24hrs of
activated prothrombin complex concentrate
has not been GIVEN for 24 HRS or more.
(examples of activated prothrombin complex
concentrate include Feiba, Novoseven RT)?
If inhibitor is present, is there a treatment plan to
address inhibitors as appropriate?
Additional information the prescribing provider feels is important to this review. Please specify below OR submit medical records.
Effective: 08/18/2020 C6417-A, C6418-A, C6419-A, C6420-A, C13272-A, C13274-A, C13383-A, C13384-A Page 2 of 3