Effective: 06/08/2020 Page 2 of 4
Was member
screened for TB?
Yes
No
If screening was positive for latent TB, was treatment
received for latent TB?
Yes
No
N/A
Is request for
Entyvio OR Tysabri?
Yes
No
Is use Monotherapy AND not in combination with
antineoplastic, immunosuppressive OR immunomodulating
agents (AZA, 6-MP, cyclosporine, MTX, TNF inhibitors)
Yes
No
N/A
Additional Criteria Based on Indication:
Rheumatoid Arthritis
Was there inadequate response to 3-
month trial of MTX?
Yes
No
Was there intolerance OR contraindication to MTX?
Yes
No
Were SSZ, LEF or HCQ used due to
intolerance OR contraindication to MTX?
Yes
No
Will requested medication be used concurrently with
MTX or another non-biologic DMARD such as SSZ,
LEF or HCQ?
Yes
No
Systemic Juvenile Idiopathic Arthritis
Does member have ACTIVE SYSTEMIC FEATURES such as
fever, evanescent rash, lymphadenopathy, hepatomegaly,
splenomegaly OR serositis?
(circle one): Yes No
Is synovitis in ONE OR MORE JOINTS despite 3 months treatment with
MTX OR LEF? (circle one):
Yes No
Check if ONE of
the following apply:
There are ACTIVE SYSTEMIC FEATURES (fever, evanescent rash, lymphadenopathy, hepatomegaly,
splenomegaly OR serositis) AND synovitis is in at least ONE JOINT.
There are NO ACTIVE SYSTEMIC FEATURES (fever, evanescent rash, lymphadenopathy, hepatomegaly,
splenomegaly OR
serositis) AND synovitis is in ONE OR MORE JOINTS despite 3 months treatment with MTX OR
LEF.
There are ACTIVE SYSTEMIC FEATURES (fever, evanescent
rash, lymphadenopathy, hepatomegaly
, splenomegaly, or serositis)
(circle one): Yes No
Synovitis is in ONE OR MORE JOINTS despite ONE-month treatment
with Kineret OR Actemra AND MTX OR LEF (circle one):
Yes No
Polyarticular Juvenile Idiopathic Arthritis
Was there inadequate response to 3-months trial
with MTX?
Yes
No Was there an intolerance OR
contraindication to MTX?
Yes
No
N/A
Was there trial with SSZ OR LEF for 3 months?
Yes
No
N/A
Oligoarticular Juvenile Idiopathic Arthritis
Is disease duration
> 6 months?
Yes
No
Was there documented inadequate response
OR intolerable side effect with 2 NSAIDs?
Yes, indicate drug:
No
Was there contraindication to
NSAIDs?
Yes
No
N/A
Was there inadequate response OR intolerable
side effect to 3-month trial with MTX?
Yes
No
Was there documented trial of LEF OR SSZ for 3 months?
Yes
No
N/A
Cryopyrin-Associated Periodic Syndromes
Indicate if ONE of the following
subtypes is present:
Familial Cold Auto
Inflammatory Syndrome
Muckle-Wells syndrome
Neonatal onset multi-system
inflammatory disease
Was there 3-months trial with Kineret?
Yes
No
N/A
Familial Mediterranean Fever
Was there inadequate response, intolerance OR
contraindication to colchicine at MAX indicated dose?
Yes
No
Giant Cell Arteritis
Was there inadequate response with glucocorticoids
(prednisone, methylprednisolone)?
Yes
No
Was there intolerance OR
contraindication to glucocorticoids?
Yes
No
If member had intolerance OR contraindication to
glucocorticoids, was there TRIAL with MTX OR
cyclophosphamide?
Yes
No
N/A
Will medication be used in
combination with tapering
course of glucocorticoids
Yes
No
Ankylosing Spondylitis
Was there inadequate response to ONE-
month trial of TWO NSAIDs?
Yes
No
Is there contraindication OR
intolerance to oral NSAIDs?
Yes
No
N/A
Psoriatic Arthritis
Does member have ACTIVE Psoriatic Arthritis?
Yes
No
Was there inadequate response to 3-
months trial with MTX?
Yes
No
Was there intolerance OR
contraindication to MTX?
Yes
No
N/A
Was there 3-month trial of SSZ OR LEF?
Yes
No
Is disease predominantly AXIAL OR ACTIVE ENTHESITIS / DACTYLITIS?
Yes
No
Was there inadequate response to ONE-
month trial of 2 NSAIDs?
Yes
No
Was there contraindication OR
intolerance to oral NSAIDs?
Yes
No
N/A
Plaque Psoriasis
Was there inadequate response to
MTX OR cyclosporine for ≥3 months?
Yes
No
Was there intolerance OR contraindication
to MTX OR cyclosporine for ≥3 months?
Yes
No
N/A
Is >10% BSA affected?
Yes
No Is <10% BSA affected BUT involves sensitive areas
such as hands, feet, face OR genitals?
Yes
No