REBOXETINE (‘Edronax’)
Re - boxy - teen
Why have I been prescribed reboxetine?
Reboxetine is an antidepressant. It is used to treat depression. Depression is a common condition. It is different from the
normal “ups and downs” of everyday life. People with depression may feel sad most of the time and cannot see an end to
their sadness. Tiredness and poor sleep are very common, and so are changes in appetite. Many people find that they
simply cannot enjoy any of life’s pleasures.
Depression can be treated in many ways. Certain “talking” therapies are also effective for some people. Antidepressants
can generally be relied upon to relieve the symptoms of depression in most people.
What exactly is reboxetine?
Reboxetine is a relatively new kind of antidepressant, although it has been in use for several years. It is termed a NARI
(a Noradrenaline Reuptake Inhibitor). It is not a tranquilliser or sleeping tablet. The trade or brand name of reboxetine is
Is reboxetine safe to take?
It is usually safe to have reboxetine regularly as prescribed by your doctor, but it doesn’t suit everyone. Let your doctor
know if any of the following apply to you, as extra care may be needed:
a) if you have epilepsy, suffer from prostate problems, glaucoma, urinary retention, or heart, liver or kidney trouble
b) If you are taking any other medication, especially if for heart problems;
c) if you are pregnant, breast feeding, or wish to become pregnant.
What is the usual dose of reboxetine?
The starting dose of reboxetine is usually 4mg twice a day. The maximum dose of reboxetine is 6mg twice a day.
How should I take reboxetine?
Look at the label on your medicine; it should have all the necessary instructions on it. Follow this advice carefully. If you
have any questions, speak to your pharmacist, doctor or nurse. Most medicines are now dispensed with an information
leaflet for you to read.
What should I do if I miss a dose?
Never change your dose without checking with your doctor. If you forget a dose, take it as soon as you remember, as long
as it is within a few hours of the usual time.
Is reboxetine addictive?
Reboxetine is not addictive, although some people do get some “discontinuation” effects if they stop taking some other
antidepressants suddenly. These effects include anxiety, dizziness, feeling sick and not being able to sleep. Some people
feel confused and out of sorts. It is best to discuss this with your doctor. These types of symptoms are extremely rare
with reboxetine.
What will happen to me when I start taking reboxetine?
All antidepressants work slowly. People tend to feel better over a period of weeks rather than days. Different symptoms
may get better at different times. Most people find that they feel noticeably better after about two or three weeks. However,
the full effect of antidepressants is usually felt only after about four to six weeks. It is very important to continue to take
antidepressants so that the full effects can be felt. Speak to your pharmacist, doctor or nurse if you have any questions
about this.
Unfortunately, you might get some side effects before you start to feel any better. Most side effects should go away after a
few weeks. Look at the table over the page. It tells you what to do if you get any side effects. Not everyone will get the side
effects shown. There are many other possible side effects. Ask your pharmacist, doctor or nurse if you are worried about
anything else that you think might be a side effect.
Side effect What is it? What should I do if it happens to me?
CONSTIPATION Feeling "bunged up" inside. You can't pass a
motion or stool.
Eat more fibre e.g. bran, fruit and vegetables. Do more
walking. Make sure you drink plenty of fluid. A mild laxative
from a pharmacy might help.
DIZZINESS Feeling light-headed and faint. Don't stand up too quickly. Try and lie down when you feel it
coming on. Don't drive.
DRY MOUTH Not much saliva or spit. Sugar-free boiled sweets, chewing gum or eating citrus fruits
usually helps. If not, your doctor can give you a mouth spray.
A change in medicine or dose may be possible.
INSOMNIA Not able to sleep at night If you are worried, contact your doctor. Try taking your second
dose of the day in the evening rather than late at night.
SWEATING Sweating more than normal. If it is bad, see your doctor.
IMPOTENCE Difficulty in getting or keeping an erection. Contact your doctor. He/she may be able to give you another
antidepressant that doesn’t cause this problem
A low blood pressure. This can make you
feel dizzy especially when you stand or get
out of bed too quickly.
Try not too stand up or get out of bed too quickly. If you feel
dizzy, don’t drive. This dizziness is not dangerous. It may
happen more at doses above 12mg a day.
TACHYCARDIA A fast heart beat. It may feel like palpitations. This is not usually dangerous. It can easily be treated if it lasts
a long time.
Difficulty in passing urine, especially if you
are a man.
Contact your doctor now.
VERTIGO Dizziness and light headedness. You may
also feel sick.
Contact your doctor.
What about alcohol?
It is officially recommended that people taking reboxetine should not drink alcohol. This is because both reboxetine and
alcohol can cause drowsiness. If the two are taken at the same time, severe drowsiness can result. This can lead to falls or
accidents. As well as this, drinking alcohol often makes depression worse. Excessive drinking is especially likely to do this.
Once people are used to taking medication, they can sometimes drink alcohol in small amounts without any harm. Avoid
alcohol altogether for the first one or two months. After this, if you want a drink, try a glass of your normal drink and see
how you feel. If this doesn’t make you feel drowsy, then it is probably OK to drink small amounts. It pays to be very cautious
because alcohol affects people in different ways, especially when they are taking medication.
Don’t stop taking your medication because you fancy a drink at the weekend. If you do drink alcohol, drink only small
amounts. Never drink any alcohol and drive while on reboxetine. Discuss any concerns you may have with your doctor or
When I feel better, can I stop taking reboxetine?
No. If you stop taking reboxetine, your original symptoms may return. To reduce your chances of becoming depressed
again, you may need to take your antidepressant for at least 6 months after you feel better, and sometimes longer. This is
not thought to be harmful. You should decide with your doctor when you can come off it.
Remember, leaflets like this can only describe some of the effects of medication. You may find other
books or leaflets also useful. If you have access to the internet you may find a lot of information
there as well, but be careful, as internet based information is not always accurate.
2001 United Kingdom Psychiatric Pharmacy Group
This leaflet is to help you understand about your medicine. It is not an official manufacturer's Patient Information Leaflet.
For more information call the UKPPG National Telephone Helpline, 11am to 5pm, Monday to Friday on 020 7919 2999 or
This leaflet has been supplied by:
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